NSF PAR Search | NSF Public Access Repository

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

Computational investigation on lipid bilayer disruption induced by amphiphilic Janus nanoparticles: combined effect of Janus balance and charged lipid concentration

https://doi.org/10.1039/D3NR00403A

Nguyen, Danh; Wu, James; Corrigan, Patrick; Li, Ying (October 2023, Nanoscale)

The anisotropic properties of Janus NPs are crucial for their ability to disrupt the negative-surface bacterial membrane modelviathe combination of hydrophobic and electrostatic interactions.
more » « less
Full Text Available
Evidence of Atypical Structural Flexibility of the Active Site Surrounding of an [FeFe] Hydrogenase from Clostridium beijerinkii

https://doi.org/10.1021/jacs.2c13458

Corrigan, Patrick S.; Majer, Sean H.; Silakov, Alexey (May 2023, Journal of the American Chemical Society)

Full Text Available
Anaerobic Infrared Spectroelectrochemical Methods for Studying Oxygen-Sensitive [FeFe] Hydrogenases

https://doi.org/10.1007/978-1-0716-3080-8_4

Corrigan, Patrick; Silakov, Alexey (January 2023, Springer US)

[FeFe] hydrogenases comprise an important class of H2 evolving enzymes; however, these proteins are often oxygen sensitive and require anaerobic environments for characterization. Understanding the electrochemical relationships between various active and inactive states of these enzymes is instrumental in uncovering the reaction mechanisms of the complex six-iron active center of [FeFe] hydrogenases called H-cluster. Since states of the H-cluster exhibit distinct fingerprint-like spectra in the mid-IR range, IR spectroelectrochemical experiments provide a powerful methodological framework for this goal. This chapter describes protocols for performing Fourier-transform infrared (FTIR) spectroelectrochemical experiments on [FeFe] hydrogenases under anaerobic conditions. Topics included experimental design, data acquisition, and data analysis.
more » « less
Full Text Available
Investigation of the Unusual Ability of the [FeFe] Hydrogenase from Clostridium beijerinckii to Access an O ₂ -Protected State

https://doi.org/10.1021/jacs.0c04964

Corrigan, Patrick S.; Tirsch, Jonathan L.; Silakov, Alexey (July 2020, Journal of the American Chemical Society)
null (Ed.)
Full Text Available

Search for: All records